Molecular and Cellular Biophysics
CHEM 309
Fall 2015
 Section:
01

Crosslisting:
MB&B 309, CHEM 509, MB&B 509, PHYS 339, PHYS 539 
Course Cluster: Health Studies 
This course is an integrated consideration of the biophysics and biophysical chemistry of biological systems from molecules to cells. The objective is to develop a critical sense of the quantitative data currently being obtained from microscopy to spectroscopy, considering both ensemble and singlemolecule experiments, and to gain familiarity and facility with interpretation using mathematical and computational models. Biological systems are inherently complex, and some form of modeling is always involved in developing an explanation of how they work. However, these models typically involve only a few basic constructs (simple harmonic motion, ideal fluids, twostate Ising models, random walks, electrostatic interactions, classical dynamics, rate equations, QM energy levels, distribution functions, and network analysis) and only elementary aspects of linear algebra, calculus, differential equations, and statistics. This course deals with how these constructs are integrated in the framework of Boltzmann statistical mechanics to formulate mathematical models of biological phenomena, how these models are validated and refined, and how they are used to form explanations and make testable predictions. Model systems to be considered include the nucleosome, the ribosome, membrane dynamics and ion channels, molecular devices and motors, prototype signal transduction systems, and regulatory processes. This course is suitable for physics and chemistry students who wish to learn about biological applications and for molecular and cellular biology students to develop skills with quantitative physicochemical modes of inquiry applied the life sciences. 
Credit: 1 
Gen Ed Area Dept:
NSM CHEM 
Course Format: Lecture  Grading Mode: Graded 
Level: UGRD 
Prerequisites: (CHEM251 AND CHEM252) 

Fulfills a Major Requirement for: (CHEMTrack A)(CHEMTrack B)(MB&B) 

Past Enrollment Probability: 75%  89% 
SECTION 01 
Major Readings: (If discrepancies exist between major readings in Wesmaps and the results generated by the Text Book Information link, defer to the readings posted in Broad Street Books.) Text Book Information
R. Phillips et al, PHYSICAL BIOLOGY OF THE CELL, 2ND ED, ISBN13:9780815344506 Philip Nelson, BIOLOGICAL PHYSICS: ENERGY, INFORMATION, LIFE, 1ST ED., ISBN13:9780716798972

Additional Requirements and/or Comments: The level of this course is keyed to graduate and undergraduate students interested in participating in the Molecular Biophysics Program at Wesleyan. Suitable also as an elective for biological chemistry majors and any interested graduate students from NSM departments. Prerequisites: For graduate students, none. For undergraduates, at least two years of courses toward a major in the natural sciences and mathematics, plus differential and integral calculus. 
Instructor(s): Beveridge,David L. Etson,Candice Marie Times: ..T.R.. 02:40PM04:00PM; Location: SCIE72; 
Total Enrollment Limit: 19   SR major: 7  JR major: 7   
Seats Available: 12  GRAD: 0  SR nonmajor: 2  JR nonmajor: 3  SO: 0  FR: 0 
Web Resources: Moodle 

