Basic genetics states that individuals with different DNA sequences express different traits. However, a large number of permanent and heritable changes to cells and organisms occur in the absence of changes to DNA sequence. Such epigenetic mechanisms explain a variety of disparate observations, including the ability of a zygote to develop into dozens of distinct cell types in multicellular organisms using one common DNA blueprint, the observation that grandchildren of individuals subject to famine have higher rates of metabolic defects, and the ability of neurons to mediate formation of long-term memories. In this course we will use a variety of examples from cell biology and genetics to examine the template-dependent processes governing the perpetuation of discrete phenotypes. Topics will include the molecular biology of prions (infectious proteins) and environment-induced alterations in gene expression that may be transmitted to offspring.
||Gen Ed Area Dept:
|Course Format: Lecture||Grading Mode: Graded|
||Fulfills a Major Requirement for: (BIOL)(MB&B)
||Past Enrollment Probability: 50% - 74%
|Major Readings: Wesleyan RJ Julia Bookstore
Articles from the primary literature will be supplemented with handouts from the instructor.
|Examination and Assignments: |
In class exams, short homework essay assignments, and short in class presentations by students.
|Additional Requirements and/or Comments: |
MB&B 208 recommended but not required.
Advanced undergraduates are encouraged to take this course.
|Instructor(s): Holmes,Scott G. Times: ..T.R.. 09:00AM-10:20AM; Location: SCIE139; |
|Total Enrollment Limit: 19||SR major: 5||JR major: 4|| || |
|Seats Available: 1||GRAD: 10||SR non-major: 0||JR non-major: 0||SO: 0||FR: 0|