Receptors, Channels, and Pumps: Advanced Topics in Membrane Protein Structure and Function|
Fall 2018 not offered
NS&B 303, MB&B 523|
Membrane proteins constitute one-third of all cellular proteins and one-half of current drug targets, but our understanding of their structure and function has been limited in the past by technological obstacles. In spite of this, the past 10 years have yielded a wealth of new membrane protein structures that have helped to uncover the mechanistic underpinnings of many important cellular processes. This class will examine some of the new insights gained through the various techniques of modern structural biology. We will start with a general review of membrane properties, structural techniques (e.g., x-ray crystallography, EM, NMR), and protein structure analysis. We will then look at common structural motifs and functional concepts illustrated by different classes of membrane proteins. Students will read primary literature sources and learn how to gauge the quality and limitations of published membrane protein structures. These tools will be generally applicable to evaluating soluble protein structures as well.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Graded|
||Prerequisites: (CHEM251 AND CHEM252 AND [MB&B208 or BIOL208])
||Fulfills a Major Requirement for: None
|Examination and Assignments: |
Student participation in class discussions, presentation of papers, weekly questions related to the readings, take-home final.