MB&B 535
Fall 2018
| Section:
01
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| Crosslisting:
MB&B 335, CHEM 335, CHEM 535 |
| Certificates: Molecular Biophysics |
| Course Cluster: Health Studies |
Amyloidogenesis, the process by which proteins and peptides misfold to form amyloid fibers, is at the root of several different diseases, including Parkinson's disease, Alzheimer's disease, mad cow disease, and type II diabetes to name a few. This course will focus on current research in the field that seeks to understand why a functional, well-folded protein adopts the misfolded amyloid form. In the course of discussing the misfolded nature of these proteins, we will review central elements of protein structure and stability to better understand the protein-folding landscape and the process of misfolding. We will also discuss how the process of misfolding leads to the different diseases and disease pathologies. We will read current literature that studies the molecular nature of these diseases and discuss the strategies used to detect, identify and study these misfolded proteins in the body and in the test-tube. |
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| Credit: 1 |
Gen Ed Area Dept:
NSM MB&B |
| Course Format: Lecture / Discussion | Grading Mode: Graded |
| Level: GRAD |
Prerequisites: MB&B208 OR MB&B325 |
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Fulfills a Major Requirement for: (CIS)(MB&B)(MOBI-MN) |
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Past Enrollment Probability: 90% or above |
| SECTION 01 |
Major Readings: Wesleyan RJ Julia Bookstore
Selected readings from scientific journals such as Biochemistry, Science, Nature, Molecular Cell.
Review articles from Annual Reviews in Biochemistry, Current Opinion in Structural Biology and other similar journals.
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Examinations and Assignments:
Problem sets, One in-class presentation, one exam |
| Instructor(s): Mukerji,Ishita Times: ..T.R.. 01:20PM-02:40PM; Location: SCIE74; |
| Total Enrollment Limit: 19 | | SR major: 7 | JR major: 6 | | |
| Seats Available: 12 | GRAD: 6 | SR non-major: 0 | JR non-major: 0 | SO: X | FR: X |
| Drop/Add Enrollment Requests | | | | | |
| Total Submitted Requests: 0 | 1st Ranked: 0 | 2nd Ranked: 0 | 3rd Ranked: 0 | 4th Ranked: 0 | Unranked: 0 |
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